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Automotive differentials
Holeňa, Vít ; Píštěk, Václav (referee) ; Kaplan, Zdeněk (advisor)
This bachelor thesis is about automotive differentials. The aim of thesis was to create an overview of various types of differentials, primarily self-locking. First chapter is dedicated to transmission of which the differential is a part of. Second chapter is about differential function in general. In third chapter, attention is paid to self-locking differentials, especially to Torsen differentials. Last of all, fourth chapter is about active differentials and systems, which help us to overcome disadvantages of differentials mentioned above.
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Personal car differentals
Csémi, András ; Kloss, Ondřej (referee) ; Kaplan, Zdeněk (advisor)
This bachelor’s thesis deals with the topic of car differentials with special attention to self-locking differentials. The first part is dedicated to the description of the powertrain. Then the main part is about the differentials, their division, the description of the constructions and the principle of function, with a focus on self-locking types. The aim of the thesis was to create a summary of self-locking differentials.
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Differentials of road and racing vehicles
Kopeček, Martin ; Hejtmánek, Petr (referee) ; Vančura, Jan (advisor)
This bachelor's thesis deals with background research of differentials of road and racing vehicles. There are listed the most commonly used types. For each type is explained by the principles of design and function. Priority, there are described the most commonly used types and types with interesting technical solutions. The race differentials, I tried to describe their possible settings.
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Engine Block with Integrated differential for Formula Student
Marek, Jiří ; Šebela, Kamil (referee) ; Janoušek, Michal (advisor)
The diploma thesis deals with the design of the integration of limited slip differential of the formula student car into the engine block. To select suitable solution from several considered, a research analysis of possible concepts was first made and then the best possible solution was determined using a decision table. A 3D model was then made for the selected concept based on the original engine block, digitalized by using a laser 3D scanner. The resulting model was then evaluated and built into Dragon X.
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Antidepressant potential of serotonergic psychedelics in preclinical research
Dušková, Valentýna ; Vejmola, Čestmír (advisor) ; Skálová, Kateřina (referee)
The treatments for depression available in contemporary medicine have a number of drawbacks. Modern antidepressants, despite fewer side effects than conventional ones, have a slow onset of action and their effectiveness is often individual. Recent studies of psychedelics have indicated their promising to extraordinary potential in the treatment of depression. Clinical research has made significant progress in this direction, as have a growing number of preclinical studies. Psychedelics potentiate signaling pathways and protein expression related to neurogenesis and cell viability and induce an increase in dendritic spines and dendritic branching. At the behavioural level, psychedelics have been shown to attenuate depressive behavioural changes, suppressing anxiety and anhedonia. This paper summarizes the effects of psychedelics in preclinical in vitro and in vivo studies, taking into account the neurobiology of depression, i.e., mainly at the level of neuroplasticity and observed behavioural changes. The first part of the thesis is devoted to the general characteristics of depression and psychedelics, followed by an introduction to preclinical experimental approaches. The central part then describes and discusses individual studies. Keywords: depression; animal models; psychedelics; LSD;...
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Engine Block with Integrated differential for Formula Student
Marek, Jiří ; Šebela, Kamil (referee) ; Janoušek, Michal (advisor)
The diploma thesis deals with the design of the integration of limited slip differential of the formula student car into the engine block. To select suitable solution from several considered, a research analysis of possible concepts was first made and then the best possible solution was determined using a decision table. A 3D model was then made for the selected concept based on the original engine block, digitalized by using a laser 3D scanner. The resulting model was then evaluated and built into Dragon X.
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Sociological interpretation of hippies movement
Koropecká, Markéta ; Duffková, Jana (advisor) ; Sládek, Jan (referee)
My bachelor thesis explores the hippie movement, which emerged in the middle of the sixties in the United States of America. The theoretical framework consists of sociological concepts of culture, subculture, youth and youth subcultures, communities, communes and social movements. The hippie movement was young people's response to middle class consumerism, which preferred material prosperity to moral and cultural values. The American transcendentalist movement and the Beat Generation can be considered its intellectual precursor. The movement's main characteristic was rejection of middle class values. Therefore, some authors have called it a counterculture. Hippies gave up studies and tangible assets. Typical for them was lack of confidence in the future, interest in oriental philosophy and religion, close relationship to nature, specific clothing style, living in communes and the use of drugs, especially LSD. The movement dissipated at the end of the sixties. Its influence is still evident in the effort to fight for human rights, peace, free network, but also in music and clothing. Some of the hippie movement's ideas are the source of today's youth subcultures and movements. Key words: social movement, youth, community, hippies, LSD
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The effect of psilocybin on memory consolidation in rats
Chona, Kembe ; Olejníková, Lucie (advisor) ; Petrásek, Tomáš (referee)
Psychedelics are currently being researched due to their long-lasting antidepressant, anxiolytic and neuroplasticity inducing actions. The mechanism by which they induce these effects remains poorly understood. Here, we decided to investigate a relatively unexplored possibility. A potential interaction of psilocybin administration and sleep and their combined effects on memory consolidation. Memory formation in animals and humans is greatly influenced by sleep manipulation which led us to assess the possibility with spatial memory tasks. We hypothesized that acute psilocybin administration after learning may have a beneficial influence on memory consolidation in rats. To determine whether an interaction with sleep exists we also subjected the rats to combinations of psilocybin and control vehicle with normal sleep and sleep deprivation. Our data did not suggest such an interaction exists. Secondly, we tried to find out if psilocybin and sleep manipulation leads to changes in neuroplasticity-related events. A process that could very likely be the basis of such a proposed beneficial effect. For this purpose, we analysed the expression of the immediate-early gene Arc and the immature neuron marker doublecortin in the rat hippocampus. Doublecortin's expression was not influenced by any of the factors....
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Serotonergic hallucinogenes and their therapeutic use
Bouberl, David ; Novotný, Jiří (advisor) ; Vejmola, Čestmír (referee)
Serotonergic hallucinogens are a group of substances that induce changes in consciousness based on their affinity for some of the serotonin receptors - especially 5-HT2A. The best known substances in this group include LSD, psilocybin or mescaline. During the 1950's and 1960's, initial research into the therapeutic uses of these substances took place, but studies from this period did not meet today's methodological standards. However, the results of recent studies point to the potential therapeutic use of psilocybin or LSD in the treatment of depression / anxiety, addiction and OCD. The aim of this work is to summarize current knowledge about selected serotonergic hallucinogens, their chemical properties, mechanisms of action and especially about the possibilities of using these substances in psychotherapy.
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Automotive differentials
Holeňa, Vít ; Píštěk, Václav (referee) ; Kaplan, Zdeněk (advisor)
This bachelor thesis is about automotive differentials. The aim of thesis was to create an overview of various types of differentials, primarily self-locking. First chapter is dedicated to transmission of which the differential is a part of. Second chapter is about differential function in general. In third chapter, attention is paid to self-locking differentials, especially to Torsen differentials. Last of all, fourth chapter is about active differentials and systems, which help us to overcome disadvantages of differentials mentioned above.
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